Intestinal Gas (Belching, Bloating, Flatulence)

Medically Reviewed on 6/22/2023

What is intestinal gas and gas pain?

A Women With Painful Intestinal Gas
Intestinal gas can be painful and embarrassing.

Intestines normally contain gas that travels through the small intestine to the colon (large intestine). The amount of gas that is usually present depends on the effects of colonic bacteria on the undigested food that reaches the colon and the speed with which the gas passes through the intestines and is passed. In healthy individuals, most of the lower intestinal gas that is given (flatus) is produced in the colon and is not transmitted from the upper intestines.

The definition of excessive gas varies by individual, usually based on what they have considered normal in the past. Some individuals consider excessive gas to be excessive belching or excessive burping, others excessive passing of gas (flatulence), and still others as the sensation of fullness in the abdomen. Although everyone goes through periods of excessive gas, particularly flatulence, it is only when the symptoms become chronic that people become concerned

What causes flatulence (gas)?

Flatulence, also known as farting, is the act of passing intestinal gas from the anus. The average person farts less than 20 times per day. Gas in the gastrointestinal tract has only two sources. It is either swallowed by air or is produced by bacteria that normally inhabit the intestines, primarily the colon. Swallowed air rarely is the cause of excessive flatulence.

The source of excessive gas is intestinal bacteria. The bacteria produce the gas (primarily hydrogen and/or methane) when they digest foods, mainly sugars and nondigestible polysaccharides (for example, starch, cellulose), that have not been digested during passage through the small intestine. The bacteria also produce carbon dioxide, but the carbon dioxide is so rapidly absorbed from the intestine that very little passes into the flatus.

Sugars

Sugars that are commonly digested poorly (maldigested) and malabsorbed are lactose, sorbitol, and fructose.

  • Lactose is the sugar in milk. The absence of the enzyme lactase in the lining of the intestines, which is a genetic trait, causes maldigestion. Lactase is important because it breaks apart the lactose into its two components sugars, glucose, and galactose so that they can be absorbed.
  • Sorbitol is a commonly used sweetener in low-calorie foods.
  • Fructose, primarily high-fructose corn syrup, is a commonly used sweetener in all types of candies and drinks. It also may be found in higher amounts in some fruits and vegetables.

Polysaccharides

Starches are another common source of intestinal gas. Starches are polysaccharides that are produced by plants and are composed of long chains of sugars, primarily fructose. Common sources of different types of starch include wheat, oats, potatoes, corn, and rice.

  • Rice is the most easily digested starch, and little undigested rice starch reaches the colon and the colonic bacteria. Accordingly, the consumption of rice produces little gas.
  • In contrast, some of the starches in wheat, oats, potatoes, and, to a lesser extent, corn, all may reach the colon. These starches, therefore, may result in the production of appreciable amounts of gas.
  • The starch in whole grains produces more gas than the starch in refined (purified) grains. Thus, more gas is formed after eating foods made with whole wheat flour than with refined wheat flour. This difference in gas production probably occurs because of the fiber (similar to a complex starch) present in whole-grain flour. Much of this fiber is removed during the processing of whole grains into refined flour.
  • Finally, certain fruits and vegetables, for example, beans and cabbage, also contain poorly digested starches that reach the colon and are easily converted by bacteria into gas.
  • Most vegetables and fruits contain cellulose, another type of polysaccharide that is not digested at all as it passes through the small intestine. However, unlike sugars and other starches, cellulose is used only very slowly by colonic bacteria. Therefore, the production of gas after the consumption of fruits and vegetables usually is not great unless the fruits and vegetables also contain sugars or polysaccharides other than cellulose.

Individuals continuously swallow small amounts of air, and bacteria constantly produce gas. Contractions of the intestinal muscles normally propel the gas through the intestines and cause the gas to be expelled. Flatulence (passing intestinal gas) prevents gas from accumulating in the intestines.

However, there are two other ways in which gas can escape the intestine besides flatulence.

  • First, it can be absorbed across the lining of the intestine into the blood. The gas then travels in the blood and ultimately is excreted by the lungs in the breath.
  • Second, gas can be removed and used by certain types of bacteria within the intestine. Most of the gas that is formed by bacteria in the intestines is removed by other bacteria in the intestines. (Thank goodness!)

What causes belching or burping?

Belching, also known as burping (medically referred to as eructation), is the act of expelling gas from the stomach out through the mouth. The usual cause of belching is a distended (inflated) stomach caused by swallowed air. Stomach distension causes abdominal discomfort, and the belching expels the air and relieves the discomfort.

Common reasons for swallowing large amounts of air (aerophagia) are gulping food or drinking too rapidly anxiety and carbonated beverages. People are often unaware that they are swallowing air. For infants, burping them during bottle or breastfeeding is vital to expel air in the stomach that has been swallowed with the formula or milk.

Excessive air in the stomach is not the only cause of belching. For some people, belching becomes a habit that does not reflect the amount of air in their stomachs. For others, belching is a response to any type of abdominal discomfort and not just to discomfort due to increased gas. Most people know that when they have mild abdominal discomfort, belching often relieves the problem. This is because excessive air in the stomach often is the cause of mild abdominal discomfort. As a result, people belch whenever they feel mild abdominal discomfort regardless of its cause.

Belching is not the simple act that many people think it is; it requires the coordination of several activities.

  • The larynx must be closed off so that any liquid or food that might return with the air from the stomach won't get into the lungs.
  • This is accomplished by voluntarily raising the larynx as is done when swallowing.
  • Raising the larynx also relaxes the upper esophageal sphincter so that air can pass more easily from the esophagus into the throat.
  • The lower esophageal sphincter must open so that air can pass from the stomach into the esophagus.
  • While all this occurs, the diaphragm descends just as it does when a person takes a breath.
  • This increases abdominal pressure and decreases pressure in the chest.
  • The changes in pressure promote the flow of air from the stomach in the abdomen to the esophagus in the chest.

One unusual type of belching has been described in individuals who habitually belch. It has been demonstrated that during their belches, the air in the room enters the esophagus and is immediately expelled without even entering the stomach, giving rise to a belch. This in-and-out flow of air is also likely to be the explanation for the ability of many people to belch at will, even when there is little or no air in the stomach. Such belching is referred to as esophageal belching.

If the problem causing the discomfort is not excessive air in the stomach, then belching does not provide relief from the discomfort. When belching does not ease the discomfort, it might be a sign that something may be wrong with the abdomen, and the cause of the discomfort should be sought. However, belching by itself does not help the physician determine what may be wrong because it can occur in virtually any abdominal disease or condition that causes abdominal discomfort.

QUESTION

Bowel regularity means a bowel movement every day. See Answer

What causes bloating?

It is important to distinguish between bloating and distention.

  • Bloating is the subjective sensation (feeling) that the abdomen is full or larger than normal and, thus, is akin to the symptom of discomfort.
  • In contrast, distention is the objective determination (physical finding) that the abdomen is larger than normal. Distention can be determined by such observations as the inability to fit into clothes, the need to loosen the belt, or looking down at the stomach and noting that it is larger than normal.

In some instances, bloating may represent a mild form of distention since the abdomen does not become physically (visibly or measurably) enlarged until its volume increases by one quart. Bloating and even mild cases of distention may be caused by the relaxation of the abdominal wall muscles and the downward movement of the diaphragm.

There are three causes of abdominal distention: an increase in 1) air, 2) fluid, or 3) tissue within the abdomen. The diseases or conditions that cause these increases are very different from one another. Therefore, it is important to determine whether air, fluid, or tissue is distending the abdomen.

There are two types of distention: continuous and intermittent.

  • Continuous distention may be caused by the enlargement of an intra-abdominal (within the abdomen) organ, an intra-abdominal tumor, a collection of fluid within the peritoneal cavity, and the space surrounding the intra-abdominal organs (ascites), or just plain obesity.
  • Intermittent distention is usually due to gas and/or occasionally, fluid within the stomach, small intestine, or colon.

What causes intermittent abdominal bloating/distention?

Excessive gas

Excessive production of gas by bacteria is a common cause of intermittent abdominal distention and bloating. Theoretically, bacteria can produce too much gas in three ways.

  1. First, the amount of gas that bacteria produce may vary from individual to individual. In other words, some individuals may have bacteria that produce more gas, either because there are more bacteria or because their particular bacteria are better at producing gas.
  2. Second, there may be poor digestion and absorption of foods in the small intestine, allowing more undigested food to reach the bacteria in the colon. The more undigested food the bacteria have, the more gas they produce. Examples of diseases that involve poor digestion and absorption include lactose intolerance, pancreatic insufficiency, and untreated celiac disease.
  3. Third, bacterial overgrowth can occur in the small intestine. Under normal conditions, the bacteria that produce gas are limited to the colon. In some conditions, these bacteria spread back into the small intestine. When this bacterial spread occurs, food reaches the bacteria before it can be fully digested and absorbed by the small intestine. Therefore, the colonic-type bacteria that have moved into the small intestine have a lot of undigested food from which to form gas. This condition, in which the gas-producing bacteria move into the small intestine, is called bacterial overgrowth of the small intestine or small intestinal bacterial overgrowth (SIBO).

Excessive production of gas by bacteria usually is accompanied by flatulence. Increased flatulence may not always occur; however, gas can be eliminated in other ways such as absorption into the body, utilization by other bacteria, or possibly, elimination at night without the awareness of the gas passer.

Physical obstruction

An obstruction (blockage) can occur virtually anywhere from the stomach to the rectum. When the blockage is temporary or partial, it can cause intermittent abdominal bloating/distention. For example, scarring of the pylorus (pyloric stenosis) can obstruct the opening from the stomach into the intestines, thereby blocking the complete emptying of the stomach. After meals, the stomach is normally filled with food and swallowed air. Then, during the next hour or two, the stomach secretes acid and fluid, which mix with the food and assist indigestion. As a result, the stomach distends further. When the obstruction is incomplete, the food, air, and fluid eventually pass into the intestines and the bloating/distention resolves.

An obstruction in the small bowel, which is most commonly due to adhesions (scarring that kinks the intestines) from previous surgery, is another cause of intermittent abdominal distention. To make matters worse, the distention that is caused by the physical obstruction stimulates both the stomach and intestines to secrete fluid, which adds to the distension.

Severe constipation or fecal impaction (hardened stool in the rectum) can also obstruct the intestinal contents' flow and result in distension. In this case, however, the bloating or distention usually is constant and progressive and is relieved by bowel movements or removal of the impacted stool.

Functional obstruction

A functional obstruction is not caused by an actual physical blockage, but rather by the poor functioning of the muscles of the stomach or intestines that propel the intestinal contents. When these muscles are not working normally, the intestinal contents will accumulate and distend the abdomen. Examples of functional obstruction include:

  • Gastroparesis (paralysis of the stomach) of diabetes
  • Chronic intestinal pseudo-obstruction is an unusual condition in which the muscles of the small intestine do not work normally
  • Hirschsprung's disease is mostly seen in infants, in which a small stretch of colonic muscle does not contract normally due to missing nerves

Accumulating evidence shows that some patients with abdominal bloating and distention due to gas may have a functional abnormality of the intestinal muscles that prevents gas from being normally transported through the intestine and expelled. Instead, their gas accumulates in the intestine. Among patients with irritable bowel syndrome (IBS) with abdominal bloating or distention as an important symptom, the gas accumulates in the small intestine and not the colon. The gas accumulates during the day and is greatest in the evening.

Fats in food affect the intestine which mimics a functional obstruction. Dietary fat reaching the small intestine causes the transport of digesting food, gas, and liquid within the intestines to slow. This can promote the accumulation of food, gas, and liquid, and lead to bloating and/or distention.

Dietary fiber or fiber used for treating constipation can cause bloating without increasing the production of gas in the intestine. Some believe that this sensation of bloating (and possibly even distention) is caused by high-fiber foods, which slow the passage of gas through the intestine. Of course, some types of fiber may lead to increased production of gas because they are digested to some extent by colonic bacteria.

Intestinal hypersensitivity

Some people appear to be very sensitive (hypersensitive) to the distention of their intestines, and they may feel bloated even with normal amounts of digesting food, gas, and fluid in the intestine after a meal. The bloating may become aggravated or even progress to distention if the meal contains substantial amounts of fat, perhaps because fat slows the transit of gas and digestion of food out of the stomach and small intestine.

Which doctors diagnose and treat excessive gas, gas pain, belching, bloating, and flatulence?

Excessive gas, gas pain, belching, bloating, and flatulence are usually treated by a gastroenterologist.

Often, a dietitian can be of great help in dealing with specialized diets and identifying foods that can be most at fault.

How are belching, bloating/distention, and flatulence diagnosed?

Medical history

A patient's medical history is important because it directs the evaluation.

  • If the bloating or distention is continuous rather than intermittent, then enlargement of abdominal organs, abdominal fluid, tumors, or obesity causes to be considered.
  • If the bloating or distention is associated with increased flatulence, then bacteria and excessive gas production are likely factors.
  • If a diet history reveals the consumption of large amounts of milk or dairy products (lactose), sorbitol, or fructose, then the maldigestion and malabsorption of these sugars may be the cause of the distention.
  • When individuals complain of flatulence, it may be useful for them to count the number of times they pass gas for several days. This count can confirm the presence of excessive flatulence since the number of times gas is passed correlates with the total amount (volume) of passed gas. As you might imagine, it is not easy to measure the amount of passed gas. It is normal to pass gas up to 20 times a day. (The average volume of gas passed daily is estimated to be about ¾ of a quart.)
  • If an individual complains of excessive gas but passes gas less than 20 times per day, the problem is likely to be something other than too much gas. For example, the problem may be the foul odor of the gas (often due to ingestion of sulfur-containing foods), the lack of ability to control (hold back) the passing of gas, or the soiling of underwear with small amounts of stool when passing gas. All of these problems, like excessive gas, are socially embarrassing and may prompt individuals to consult a doctor. These problems, however, are not due to excessive gas production, and their treatment is different.

Simple abdominal X-rays

Simple X-rays of the abdomen, particularly if they are taken during an episode of bloating or distention, often can confirm air as the cause of the distention, since large amounts of air can be seen easily within the stomach and intestine. Moreover, the cause of the problem may be suggested by noting where the gas has accumulated. For example, if the air is in the stomach, emptying the stomach is likely to be the problem.

Small intestinal X-rays

X-rays of the small intestine, in which barium is used to fill and outline the small intestine, are particularly useful for determining whether there is an obstruction of the small intestine.

Gastric emptying studies

These studies measure the ability of the stomach to empty its contents. For gastric emptying studies, a test meal that is labeled with a radioactive substance is eaten and a Geiger counter-like device is placed over the abdomen to measure how rapidly the test meal empties from the stomach. A delay in emptying of the radioactivity from the stomach can be caused by any condition that reduces emptying of the stomach (for example, pyloric stenosis, gastroparesis).

Ultrasound, CT scan, and MRI

Imaging studies, including ultrasound examination, computerized tomography (CT), and magnetic resonance imaging (MRI), are particularly useful in defining the cause of distention that is due to enlargement of the abdominal organs, abdominal fluid, and tumor.

Maldigestion and malabsorption tests

Two types of tests are used to diagnose maldigestion and malabsorption: general tests and specific tests.

  • The best general test is a 72-hour collection of stool in which the fat is measured; if maldigestion and/or malabsorption exist because of pancreatic insufficiency or diseases of the lining of the small intestine (for example, celiac disease), the amount of fat will increase before proteins and starches in the stool.
  • Specific tests can be done for maldigestion of individual sugars that are commonly maldigested, including lactose (the sugar in milk) and sorbitol (a sweetener in low-calorie foods). The specific tests require ingestion of the sugars followed by hydrogen/methane breath testing. (See below.) Sugar fructose, a commonly used sweetener, like lactose and sorbitol, also may cause abdominal bloating/distention and flatulence. However, the problem that can occur with fructose is different from that with lactose or sorbitol. Thus, as already described, lactose and sorbitol may be poorly digested by the pancreatic enzymes and small intestine. Fructose, on the other hand, may be digested normally but may pass so rapidly through the small intestine that there is not enough time for digestion and absorption to take place.

Hydrogen/methane breath tests

The most convenient way to test for bacterial overgrowth of the small intestine is hydrogen/methane breath testing. Normally, the gas produced by the bacteria of the colon is composed of hydrogen and/or methane. For hydrogen/methane breath testing, a non-digestible sugar, lactulose, is consumed. At regular intervals following ingestion, samples of breath are taken for analysis. When the lactulose reaches the colon, the bacteria form hydrogen and/or methane. Some of the hydrogen or methane is absorbed into the blood and eliminated in the breath where it can be measured in the breath samples.

In normal individuals, there is one peak of hydrogen or methane when the lactulose enters the colon. In individuals who have bacterial overgrowth, there are two peaks of hydrogen or methane. The first occurs when the lactulose passes and is exposed to the bacteria in the small intestine. The second occurs when the lactulose enters the colon and is exposed to the colonic bacteria. Hydrogen breath testing for overgrowth also may be done utilizing lactose, glucose, sorbitol, or fructose as the test sugar.

What is the treatment for excessive intestinal gas and gas pain?

The treatment of excessive intestinal gas depends on the cause:

  • Maldigestion and/or malabsorption: If maldigestion and/or malabsorption is caused by a disease of the intestinal lining, the specific disease must be identified, most commonly through a small bowel biopsy. Then, treatment can be targeted for that condition. For example, if celiac disease is found on the biopsy, a gluten-free diet can be started.
  • Physical obstruction: If there is a physical obstruction to the emptying of the stomach or passage of food, liquid, and gas through the small intestine, then surgical correction of the obstruction is required. If the obstruction is functional, medications that promote the activity of the muscles of the stomach and small intestine are given. Examples of these medicines are erythromycin or metoclopramide (Reglan).
  • Bacterial overgrowth: Bacterial overgrowth of the small bowel usually is treated with antibiotics. However, this treatment is frequently only temporarily effective or not effective at all. When antibiotics provide only a temporary benefit, it may be necessary to treat patients intermittently or even continuously with antibiotics. If antibiotics are not effective, probiotics (for example, lactobacillus) or prebiotics can be tried although their use in bacterial overgrowth has not been studied. This condition may be difficult to treat.

What over-the-counter (OTC) medications are available to soothe and cure excessive gas?

Over-the-counter (OTC) medications to soothe and treat excessive gas include the following:

  • Beano: An interesting form of treatment for excessive gas is alpha-D-galactosidase, an enzyme that is produced by a mold. This enzyme, commercially available as Beano, is consumed as either a liquid or tablet with meals. This enzyme can break down some of the difficult-to-digest polysaccharides in vegetables so that they may be absorbed. This prevents them from reaching the colonic bacteria and causing unnecessary production of gas. Beano is effective in decreasing the amount of intestinal gas.
  • Simethicone (Phazyme; Flatulex; Mylicon; Gas-X; Mylanta Gas): It is unclear whether simethicone has an effect on gas in the stomach. However, it does not affect the formation of gas in the colon. Moreover, in the stomach, simethicone would be expected only to affect swallowed air, which, as previously mentioned, is an uncommon cause of excessive intestinal gas. Nevertheless, some individuals are convinced that simethicone helps them.
  • Activated charcoal: It is unclear whether simethicone has an effect on gas in the stomach. However, it does not affect the formation of gas in the colon. Moreover, in the stomach, simethicone would be expected only to affect swallowed air, which, as previously mentioned, is an uncommon cause of excessive intestinal gas. Nevertheless, some individuals are convinced that simethicone helps them. Activated charcoal has been shown to reduce the formation of gas in the colon, though how it does so is unknown.
  • Supplemental pancreatic enzymes: When maldigestion is due to pancreatic insufficiency, then supplemental pancreatic enzymes can be ingested with meals to replace the missing enzymes.

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

What natural or home remedies help soothe and get rid of intestinal gas and gas pain?

Natural treatments and home remedies to soothe intestinal gas and gas pain 

  • Eliminating sugars: If there is maldigestion of specific sugars—lactose, sorbitol, or fructose—the offending sugars can be eliminated from the diet. In the case of lactose in milk, an alternative treatment is available. People with lactose intolerance can add enzymes that are similar to intestinal lactase to the milk before drinking it to break down the lactose into glucose and galactose so that it can be absorbed normally. Some people find that yogurt, in which the lactose has been broken down partially by bacteria, produces less gas than milk.
  • Eliminating certain vegetables and fruits: There also are certain types of vegetables and fruits that contain types of starches that are poorly digested by people but well digested by bacteria. These include beans, lentils, cabbage, Brussels sprouts, onions, carrots, apricots, and prunes. Reducing the intake of these vegetables and fruits, as well as foods made from whole grains, should reduce gas and flatulence. However, the list of gas-producing foods is rather long, and it may be difficult to eliminate them all without severely restricting the diet.

What foods should you avoid to prevent intestinal gas?

Foods that cause gas fall into a category summarized by the acronym, FODMAP, which stands for "fermentable oligosaccharides, disaccharides, monosaccharides, and polyols."

Many people attempt a FODMAP elimination diet, but it can be difficult to eliminate these dietary constituents because they are present in a majority of foods. Any condition causing flatulence will respond to a low-FODMAP diet, but the diet is not an easy one to follow and may require the assistance of a dietitian. If the diet is successful it may be possible to add back some of the excluded foods without a recurrence of flatulence.

Examples of FODMAP foods include:

  • Oligosaccharides: Vegetables such as asparagus, garlic, leeks, onions, and lettuce. Grains such as barley, rye, and wheat. Nuts such as cashews and pistachios. Legumes such as baked beans, kidney beans, chickpeas, lentils, and soybeans
  • Disaccharides: Milk (cow, goat, or sheep, evaporated milk, ice cream, margarine, yogurt, and cheese
  • Monosaccharides: Primarily fruits such as apples, boysenberries, figs, mangoes, pears, and watermelon, as well as high-fructose corn syrup and honey
  • Polyols: Fruits such as apples, apricots, blackberries, cherries, peaches, pears, nectarines, plums, and avocados; sweeteners such as sorbitol, mannitol, and xylitol; as well as cauliflower, green pepper, mushrooms, and pumpkin

With such an extensive list of foods to be avoided, it is no surprise that a low-FODMAP diet is difficult to initiate and maintain. That is why it is most important to look for a medical condition that is responsible for excessive gas.

What is new in intestinal gas research?

One study has shed additional light on the role of intestinal gas and how it causes symptoms. Investigators studied 30 patients whose primary complaint was flatulence (although they also had other complaints such as abdominal bloating, distension, and/or discomfort) and 20 healthy people (controls) without issues related to gas.

The researchers studied the patients' and controls' production of gas and symptoms on their normal (basal) diet, during and following a standard meal, and during and following a meal that contained foods known to cause more gas (flatulent diet). During the basal period on their usual diet, not surprisingly, the patients had more symptoms than the controls and evacuated gas (farted) more often than controls (22 vs. 7 times during the day). Interestingly, however, the patients and controls produced the same total volume of gas while on the standard meal. This would suggest that the patients were NOT producing more gas than the controls. Two explanations for these observations would be:

  1. The basal diet contained more gas-producing foods
  2. Those patients were more sensitive to gas; in other words, they developed more discomfort producing the same amount of gas as controls (farting more frequently, but with less gas per fart).

On the flatulogenic diet, the controls developed some symptoms, but the patients, not surprisingly, developed worse symptoms. The number of farts increased for both patients and controls but more so for the patients (44 vs. 22 farts, respectively). Nevertheless, the total amount of gas that was produced on the flatulogenic diet was the same for controls and patients. This supported the probability that patients were more sensitive to gas, i.e., they developed more symptoms and farted more even though they were producing the same amount of gas as controls.

The observations made in this study add considerably to our understanding of intestinal gas and the mechanism whereby gas causes symptoms. In the group of patients that were studied, the symptoms were caused by an abnormal sensitivity to gas and not by the production of more gas. It is important to recognize, however, that although this may be the mechanism for the production of symptoms in this group of patients, there are undoubtedly other explanations or contributing factors in other patients with symptoms and flatulence. For example and as explained previously, some patients may retain more gas in the abdomen due to problems with the intestinal muscles leading to intestinal distention and discomfort. Some patients may be on a flatulogenic diet without realizing it, and some patients may indeed be producing more gas than others on the same diet.

Medically Reviewed on 6/22/2023
References
Azpiroz, F., et al. "Effects of Prebiotics vs a Diet Low in FODMAPs in Patients With Functional Gut Disorders." Gastroenterology 155.4 October 2018: 1004-1007.

Manichanh, C., et al. "Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet." Gut 63 (2014): 401-408.

Wilder-Smith, C.H., et al. "Fermentable Sugar Ingestion, Gas Production, and Gastrointestinal anc Central Nervous System Symptoms in Patients With Functional Disorders." Gastroenterology 155.4 October 2018: 1034-1044 e6.